Collected Item: “Organoselenium functionalized oxacycles as ligands in some trans-palladium(II) complexes: biological evaluation and interaction with small biomolecules”
Врста публикације
Рад у часопису
Верзија рада
објављена верзија
Језик рада
енглески
Аутор/и (Милан Марковић, Никола Николић)
I. Raković, D. Ćoćić, O. Milošević-Djordjević, I. Radojević, M. N. Živanović, K. Virijević, J. Pavić, J. Tubić Vukajlović, A. Marković, J. S. Marjanović, M. D. Kostić, P. Čanović, A. Mijatović, V. M. Divac
Наслов рада (Наслов - поднаслов)
Organoselenium functionalized oxacycles as ligands in some <i>trans</i> -palladium(II) complexes: biological evaluation and interaction with small biomolecules
Наслов часописа
Journal of Coordination Chemistry
Издавач (Београд : Просвета)
Informa UK Limited
Година издавања
2023
Сажетак на енглеском језику
In this article, the biological evaluation and interaction of three selenium-based trans-palladium complexes (Pd–Se1, Pd–Se2, and Pd–Se3) with small biomolecules were performed. The UV–Vis kinetic studies on substitution reaction of synthesized complexes with selected biologically important N- and S-bonding ligands (LCys, GSH, L-Met, 50-GMP, L-His) has emphasized greater affinity of sulphur-based ligands for complex-binding, while the general order of the reactivity was L-Cys > GSH > L-Met > 50-GMP > L-His. The complex reactivity toward small biomolecules is influenced by ligand flexibility, i.e. the steric hindrances of their corresponding ligands near the coordination site (Se–Pd) during the substitution process. The in vitro cytotoxicity of the investigated
complexes against colorectal carcinoma HCT-116 and healthy fibroblast MRC-5 cells exhibited moderate prooxidative and significant cytotoxic character against HCT-116 cells, while such effect on MRC-5 was much weaker. Antioxidant activity (DPPH assay) indicated that all three complexes and their ligands have
significant antioxidant activity, with Pd–Se2 being significantly stronger than its ligand L2 or the other complexes. Molecular docking simulations on tyrosinase (Tyr) singled out Pd–Se1 as the most compatible to bind to the cavity of Tyr. At all concentrations, the tested compounds demonstrated genotoxic effects (comet assay) compared to negative control.
complexes against colorectal carcinoma HCT-116 and healthy fibroblast MRC-5 cells exhibited moderate prooxidative and significant cytotoxic character against HCT-116 cells, while such effect on MRC-5 was much weaker. Antioxidant activity (DPPH assay) indicated that all three complexes and their ligands have
significant antioxidant activity, with Pd–Se2 being significantly stronger than its ligand L2 or the other complexes. Molecular docking simulations on tyrosinase (Tyr) singled out Pd–Se1 as the most compatible to bind to the cavity of Tyr. At all concentrations, the tested compounds demonstrated genotoxic effects (comet assay) compared to negative control.
Број часописа
-
Почетна страна
1
Завршна страна
20
DOI број
10.1080/00958972.2023.2256934
ISSN број часописа
0095-8972
Кључне речи на српском (одвојене знаком ", ")
Materials Chemistry,Physical and Theoretical Chemistry
Кључне речи на енглеском (одвојене знаком ", ")
Materials Chemistry,Physical and Theoretical Chemistry
Линк
https://www.tandfonline.com/doi/pdf/10.1080/00958972.2023.2256934
Шира категорија рада према правилнику МПНТ
M20
Ужа категорија рада према правилнику МПНТ
М23
Степен доступности
Затворени приступ
Лиценца
Creative Commons – Attribution-No Derivative Works 4.0 International
Формат дигиталног објекта
.pdf