Рад у часопису

објављена верзија

енглески

Nikola Stevanović, Aleksandar Mijatović, Aleksandar Lolić, Mario Zlatović, Rada Baošić

Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases

Chemical Papers

Springer Science and Business Media LLC

2021

Ispitivani su uticaji primene mono- i dvokomponentnih organskih modifikatora na određivanje lipofilnosti 12 tetradentatnih Šifovih baza metodom reverzno-fazne tankoslojne hromatografije. Osnovni cilj je da se proceni tip interakcije između posmatranih jedinjenja i komponenti primenjenih hromatografskih sistema i uspostavi neki obrazac ponašanja kako bi se lakše izabrala kombinacija organskih modifikatora koji će simulirati interakciju u biološkim sistemima na osnovu činjenica da iste osnovne intermolekularne interakcije su odgovorne za ponašanje supstanci i u biološkom i u hromatografskom sistemu. Primenjeni organski modifikator pokazuje sposobnost modifikacije površine primenjenog sorbenta, što utiče na ispoljavanje lipofilnosti posmatranih jedinjenja. Korišćeni su jednokomponentni organski modifikatori iz različitih grupa Snajderovog trougla, kao i njihove dvokomponentne smeše. Pored toga, uporedili smo eksperimentalno određene izračunate parametre lipofilnosti.

The influences of the application of mono- and two-component organic modifiers on lipophilicity determination of 12 tetradentate Schiff bases by reversed-phase thin layer chromatography were investigated. The main goal is to estimate types of interaction between observed compounds and components of the applied chromatographic systems and establish some behaviour pattern in order to easier choose a combination of organic modifiers which will simulate interaction in biological systems based on the facts that the same basic intermolecular interactions are responsible for the behaviour of substances in both the biological and chromatographic system. The applied organic modifier shows the ability to modify the surface of the applied sorbent, which affects the manifestation of lipophilicity of the observed compounds. Mono-component organic modifiers from different groups of the Snyder triangle were used, as well as their two-component mixtures. In addition, we compared experimentally determined calculated parameters of lipophilicity.

1947

9

10.1007/s11696-021-01884-5

0366-6352

Šifove baze, Lipofilnost, RP-TLC, Organski modifikatori

Schiff base, Lipophilicity, RP-TLC, Organic modifiers

https://link.springer.com/content/pdf/10.1007/s11696-021-01884-5.pdf

M20

М23

Затворени приступ

Creative Commons – Attribution-NonComercial-No Derivative Works 4.0 International

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