Рад у часопису

објављена верзија

енглески

Vera M. Divac, Aleksandar Mijatović, Marina D. Kostić, Jovana Bogojeski

The interaction of organoselenium trans-palladium(II) complexes toward small-biomolecules and CT-DNA

Inorganica Chimica Acta

Elsevier BV

2017

Serija organoselenijum trans-paladijum(II) kompleksa 1 (bis(2-(fenilselanilmetil)oksolan)dihloropaladijum(II)), 2 (bis(2-(fenilselanilmetil)oksan)dihloropaladijum(II)) i 3 (bis(2) ,2-dimetil-3-(fenilselanil)oksan)dihloropaladijum(II)) su korišćeni za ispitivanje reaktivnosti ovog specifičnog tipa kompleksa prema različitim bio-molekulima. Ovaj sistem je od posebnog interesa jer se jako malo zna o supstitucionim reakcijam organoselenijum paladijum(II) kompleksa sa trans konfiguracijom. Zamena koordinovanog hlorida sa serijom malih bio-molekula (l-Met, l-His, l-Cis, GSH i 5′-GMP) proučavana je pod uslovima pseudo-prvog reda kao funkcija koncentracije nukleofila i temperature korišćenjem tehnika zaustavljenog toka. Rezultati za proučavane komplekse ukazuju da kompleks 1 reaguje brže u odnosu na komplekse 2 i 3, što je uzrokovano sternim efektima. Sumpor-donorski bio-molekuli pokazali su bolju reaktivnost od azot-donorskih molekula. Aktivacioni parametri ukazuju da se supstitucija dešava asocijativnim mehanizmom koji je podržan značajno negativnim aktivacionim entropijama. Štaviše, interakcija ovih organoselenijum trans-paladijum(II) kompleksa sa DNK timusa teleta (CT-DNK) je dalje ispitana apsorpcionim (UV–Vis) i emisionim spektralnim studijama (studija pomeranja etidijum bromida). Sve u svemu, proučavani kompleks je pokazao dobru sposobnost interakcije sa DNK.

A series of organoselenium trans-palladium(II) complexes 1 (bis(2-(phenylselanylmethyl)oxolane)dichloropalladium(II)), 2 (bis(2-(phenylselanylmethyl)oxane)dichloropalladium(II)) and 3 (bis(2,2-dimethyl-3-(phenylselanyl)oxane)dichloropalladium(II)) have been used to investigate reactivity of this specific type of complexes toward different bio-molecules. This system is of special interest because only little is known about the substitution behavior of organoselenium palladium(II) complexes with trans configuration. The substitution of coordinated chloride by a series of small bio-molecules (l-Met, l-His, l-Cys, GSH and 5′-GMP) was studied under pseudo first-order conditions as a function of nucleophile concentration and temperature using stopped-flow technique. The results for the studied complexes indicate that the complex 1 reacts faster compared to the complexes 2 and 3, which is caused by steric effects. The sulfur-donor bio-molecules have shown better reactivity than nitrogen-donor bio-molecules. The activation parameters indicate that substitution occurs by an associative mechanism which is supported by the significantly negative activation entropies. Furthermore, the interaction of these organoselenium trans-palladium(II) complexes with calf thymus DNA (CT-DNA) was further examined by absorption (UV–Vis) and emission spectral studies (Ethidium bromide displacement studies). Overall, the studied complex exhibited good DNA interaction ability.

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10.1016/j.ica.2017.07.012

0020-1693

Pd(II), Selen, Substitucija, Kinetika, Mehanizam

Pd(II), Selenium, Substitution, Kinetics, Mechanism

https://api.elsevier.com/content/article/PII:S0020169317307363?httpAccept=text/xml

M20

М22

Отворени приступ

Creative Commons – Attribution-NonComercial-No Derivative Works 4.0 International

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