Претрага
744 items
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Definition of Circulation Conditions and Groundwater Genesis of the Complex Krupaja Hydrogeological Karst System (Eastern Serbia)
Management, Monitoring, Policy and Law,Renewable Energy, Sustainability and the Environment, Geography, Planning and Development, Building and Construction... the way to completely scientific research and research related to solving a specific engineering / geological problem or hydrotechnical problem. Analysis of the geometry of the main karst conduits in the saturated zone, as well as their connection to underground morphological objects located above ...
... channels within a karst system [4-7]. An important tool for defining , the velocity of groundwater circulation and mean residence time is isotopic analysis, which is increasingly used, and, in correlation to field research, has the potential to contribute significantly to defining, the genesis of g ...
... ArcGIS program was used, along; with some additional software [7]. Linked layers and an associated base were used to create a basis for further analysis of karst aquifers through different model components. By defining, the main directions and orientation of karst conduits (followed by a possible ...Ljiljana Vasić, Saša Milanović, Tina Dašić. "Definition of Circulation Conditions and Groundwater Genesis of the Complex Krupaja Hydrogeological Karst System (Eastern Serbia)" in Sustainability, MDPI AG (2023). https://doi.org/10.3390/su151411146
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Razvoj ARCGIS geobaze površinskog kopa korišćenjem UML CASE alata
... monitoring and managing work at open pits. It enables not only visualization, but also analysis of stored data. Data registered in this database are the following: data on geological research, physical-chemical analysis of ore samples, infrastructural objects, natural objects, work environment (pit, levels ...
... borehole different analyses are performed (petrographic-mineralogical, physical- mechanical, qualitative, which encompasses technical, elementary analysis, ash analysis and ash fusibility), and lithologic and stratigraphic characteristics are established. Results of this research are modeled by classes: Analiza ...
... mine production, and pertain to an important segment that demands visual representation. More precisely, the paper tackles exploration works, sample analysis, infrastructure within the mine and in its environment, excavating and loading equipment, etc. The physical implementation of the OpmGIS geodatabase ...Aleksandra Tomašević, Ljiljana Kolonja, Ivan Obradović, Ranka Stanković, Olivera Kitanović. "Razvoj ARCGIS geobaze površinskog kopa korišćenjem UML CASE alata" in Podzemni radovi, Beograd : Univerzitet u Beogradu - Rudarsko-geološki fakultet (2012)
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Structural characterization of traditional pottery produced from local clay, Rujište (Ražanj, Central Serbia), in an effort to preserve its geoheritage
... determination of individual minerals from the group of clays, oriented preparations (X-ray diffraction) were made. Studies conducted with a scanning electron microscope (SEM) equipped with a detector for secondary electrons (SE), back-scattered electrons (BSE), modern energy-dispersive spectrometer ...
... preservation of this type of intangible cultural heritage, inscribed in the National register of ICH and as geoheritage in Serbia as well. The analysis of the phase, mineral composition and structure of the clay body was performed by optical microscopy on cross-sections perpendicular to the vessel ...
... which is intimately mixed with clay of the illite type with a very smaller amount of detrital quartz and feldspar (Krstić et al., 1980). In the analysis of the thin sections made of the sample, the basic mass is observed, which represents a sintered fine-grained aggregate and binds large, often ...Maja Milošević, Biljana Đorđević, Alena Zdravković . "Structural characterization of traditional pottery produced from local clay, Rujište (Ražanj, Central Serbia), in an effort to preserve its geoheritage" in 9th International Conference Mineralogy and Museums, Sofia, Bulgaria, Earth and Man National Museum and Bulgarian Mineralogical Society (2021)
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Photocatalytic Activity of the V2O5 Catalyst toward Selected Pharmaceuticals and Their Mixture: Influence of the Molecular Structure on the Efficiency of the Process
Sanja J. Armaković, Aleksandra Jovanoski Kostić, Andrijana Bilić, Maria M. Savanović, Nataša Tomić, Aleksandar Kremenović, Maja Šćepanović, Mirjana Grujić-Brojčin, Jovana Ćirković, Stevan Armaković (2023)Due to the inability of conventional wastewater treatment procedures to remove organic pharmaceutical pollutants, active pharmaceutical components remain in wastewater and even reach tap water. In terms of pharmaceutical pollutants, the scientific community focuses on -blockers due to their extensive (over)usage and moderately high solubility. In this study, the photocatalytic activity of V2O5 was investigated through the degradation of nadolol (NAD), pindolol (PIN), metoprolol (MET), and their mixture under ultraviolet (UV) irradiation in water. For the preparation of V2O5, facile ...DFT analysis, metoprolol, nadolol, nanomaterial characterization, photocatalysis, pindolol, β-blocker... is the most reactive of all three considered molecules in terms of removingy an electron from it. Keywords: Bf-blocker; nadolol; pindolol; metoprolol; photocatalysis; nanomaterial characterization; DEFT analysis 1. Introduction The World Health Organization noted in its reports that pharmaceuticals ...
... structures may undergo direct and indirect transitions, and it is not often easy to decide which type of electron inter-band transition is predominant [37]. According to a detailed analysis of available literature data and the film properties, Schneider concluded that the direct allowed transition ...
... Chem. 1994, 98, 11623—11627. [CrossRef] 'Vosko, S.H.; Wilk, L.; Nusair, M. Accurate spin-dependent electron liquid correlation energjes for local spin density calculations: A critical analysis. Can. J. Phys. 1980, 58, 1200-1211. [CrossRef] Becke, A. Density-functional thermochemistry. III. The ...Sanja J. Armaković, Aleksandra Jovanoski Kostić, Andrijana Bilić, Maria M. Savanović, Nataša Tomić, Aleksandar Kremenović, Maja Šćepanović, Mirjana Grujić-Brojčin, Jovana Ćirković, Stevan Armaković. "Photocatalytic Activity of the V2O5 Catalyst toward Selected Pharmaceuticals and Their Mixture: Influence of the Molecular Structure on the Efficiency of the Process" in Molecules, MDPI AG (2023). https://doi.org/10.3390/molecules28020655
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A Model for Determining the Dependability of Continuous Subsystems in Coal Mines Using the Fuzzy Logic Approach
Nikola Stanić, Miljan Gomilanović, Petar Marković, Daniel Krzanović, Aleksandar Doderović, Saša Stepanović (2024)This study presents a unique model for assessing the dependability of continuous parts of combined systems in open-pit mining through the application of fuzzy logic. Continuous sub-systems as part of the combined system of coal exploitation in surface mines have the basic function of ensuring safe operation, high capacity with high reliability, and low costs. These subsystems are usually part of the thermal power plant’s coal supply system and ensure stable fuel supply. The model integrates various independent partial ...fuzzy logic, max-min composition, continuous part of combined system (CCS), open pit, mining, dependabilityNikola Stanić, Miljan Gomilanović, Petar Marković, Daniel Krzanović, Aleksandar Doderović, Saša Stepanović. "A Model for Determining the Dependability of Continuous Subsystems in Coal Mines Using the Fuzzy Logic Approach" in Applied Sciences, Basel, August 2024, MDPI (2024). https://doi.org/https://doi.org/10.3390/app14177947
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Rule-based Automatic Multi-word Term Extraction and Lemmatization
In this paper we present a rule-based method for multi-word term extraction that relies on extensive lexical resources in the form of electronic dictionaries and finite-state transducers for modelling various syntactic structures of multi-word terms. The same technology is used for lemmatization of extracted multi-word terms, which is unavoidable for highly inflected languages in order to pass extracted data to evaluators and subsequently to terminological e-dictionaries and databases. The approach is illustrated on a corpus of Serbian texts from ...... place with very little human intervention, starting from the tokenization and lexical analysis of a raw text up to production of dictionary entries. The system relies Unitex routines for text analysis and FST application, while one of the many functionalities of LeXimir is used to produce ...
... entity names (organization names and similar named entities found in a corpus of legislative acts) by using rules generated on the basis of corpora analysis. For tackling the problem of MWT extraction and lemmatization from Serbian texts we have chosen a rule-based approach, which relies on a system ...
... development. Unitex E-dictionaries Rule based term extraction and lemmatization Corpora Domain specific 1. Tokenization and lexical analysis Local grammars 5. DELAC dictionary production 2. Rule based MWU term extraction and normalization 3. Rule based lemma correction and ...Ranka Stanković, Cvetana Krstev, Ivan Obradović, Biljana Lazić, Aleksandra Trtovac. "Rule-based Automatic Multi-word Term Extraction and Lemmatization" in Proceedings of the 10th International Conference on Language Resources and Evaluation, LREC 2016, Portorož, Slovenia, 23--28 May 2016, European Language Resources Association (2016)
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Determining the Groundwater Balance and Radius of Influence Using Hydrodynamic Modeling: the Case Study of the Groundwater Source “Šumice” (Kikinda, Serbia)
A groundwater flow model was developed to simulate groundwater extraction from the public water supply source of the City of Kikinda. The hydrodynamic model includes the municipal groundwater source of Kikinda (Šumice and the Jezero Well), but also an extended area where there are groundwater sources that provide water supply to three factories: (MSK, TM and LŽT - Kikinda). Hydrodynamic modeling, based on the numerical method of finite differences will show the groundwater balance of the sources in the ...... existing sources that have been in service for years, but also when it comes to opening new sources. The best research approach includes hydrodynamic analysis in the early stages of planning and sound monitoring in all stages. Many authors have recently focused on this subject from different perspectives: ...
... widest sanitary protection zone [13]. Particle tracking can be used for various purposes. The backward particle tracking method with an uncertainty analysis of porosity, applying a Monte Carlo approach, with Geographic Information System (GIS) support, is a useful tool for delineating groundwater ...
... the influence of any hydraulic contact with sandy water-bearing strata that overlie the tapped horizon is avoided, because of both insufficient analysis andartificially-created groundwater renewal difficulties, which certainly affect groundwater source performance. The layer contours were geometrized ...Dušan Polomčić, Dragoljub Bajić, Jelena Zarić. "Determining the Groundwater Balance and Radius of Influence Using Hydrodynamic Modeling: the Case Study of the Groundwater Source “Šumice” (Kikinda, Serbia)" in Journal of Sustainable Development of Energy, Water and Environment Systems (2015). https://doi.org/10.13044/j.sdewes.2015.03.0017
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Threshold-induced correlations in the Random Field Ising Model
... range of threshold and disorder values. �is result is of special importance for analysis of experimental results where setting a �nite detection threshold is an inevitable procedure in order to be able to perform the analysis of the recorded signal. Qualitatively speaking, our results meet very well to ...
... range of threshold and disorder values. This result is of special importance for analysis of experimental results where setting a finite detection threshold is an inevitable procedure in order to be able to perform the analysis of the recorded signal. Qualitatively speaking, our results meet very well to ...
... intermittent bursts of activity known as avalanches with scale-invariant properties which are power-law distributed. Our findings, based on the scaling analysis and collapse of data collected in extensive simulations show that the observed correlations emerge upon applying a finite threshold to the pertaining ...Sanja Janićević, Dragutin Jovković, Lasse Laurson, Đorđe Spasojević. "Threshold-induced correlations in the Random Field Ising Model" in Scientific Reports, Springer Science and Business Media LLC (2018). https://doi.org/10.1038/s41598-018-20759-6
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Definisanje parametara čvrstoće na smicanje kod izvođenja kosina u ispucalom stenskom masivu
Zoran M. Berisavljević (2016-04-01)Definisanje parametara čvrstoće na smicanje ispucalih stenskih masa predstavlja jedanod najzahtevnijih zadataka mehanike stena. Geotehnička istraživanja su uglavnomograničena na rezultate laboratorijskih ispitivanja malih makroskopski homogenihuzoraka, sa kojih se vrši ekstrapolacija rezultata na terensku razmeru. Ispitivanja semogu vršiti in situ, ali su i ona ograničena veličinom korišćene aparature imikrolokacijom na kojoj se vrše ispitivanja. Pored toga, moguće je vršiti različitaispitivanja na fizičkim modelima, koja su veoma složena i skupa. Ekstrapolacijapodataka sa malog uzorka na terensku razmeru daje mnogo bolje rezultate ...naponsko stanje, ispucalost, heterogenost, čvrstoća na smicanje, geološki indeksčvrstoće, Hoek-Brownov materijal, kompozitni uzorci, dezintegracija, povratna analizaZoran M. Berisavljević. "Definisanje parametara čvrstoće na smicanje kod izvođenja kosina u ispucalom stenskom masivu" in Универзитет у Београду, Универзитет у Београду, Рударско-геолошки факултет (2016-04-01)
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Simulacija isticanja odabranih karstnih vrela pirotske kotline
Saša Milanović, Branislav Petrović, Vesna Ristić Vakanjac, Ljiljana Vasić, Veljko Marinović, Petar Vojnović (2022)Analiza recesije, autokorelaciona i kroskorelaciona analiza vremenskih serija padavina i isticanja podzemnih voda karstnih vrela Krupac i Gradište (Stara planina, JI Srbija) izvršena je radi formiranja stohastičkog autoregresivno-krosregresivnog modela (ARCR) i kratkoročne prognoze dnevnih vrednosti izdašnosti. Usled postojanja heterogenosti i anizotropnosti karstne izdani veoma je komplikovano i zahtevno odrediti prostornu distribuciju podzemnih voda u okviru karstnog hidrogeološkog sistema, te je primenljivost determinističkih modela minimizirana. Stoga je upotreba stohastičkog modela u ovom slučaju svrsishodnija. Autokorelogram izdašnosti vrela Krupac pokazao je ...Saša Milanović, Branislav Petrović, Vesna Ristić Vakanjac, Ljiljana Vasić, Veljko Marinović, Petar Vojnović. "Simulacija isticanja odabranih karstnih vrela pirotske kotline" in Vodoprivreda, Српско друштво за одводњавање и наводњавање, Београд, Академија инжењерских наука Србије (2022)
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Regionalna karakterizacija karstnih podzemnih voda dela centralnog Balkana u funkciji njihovog održivog korišćenja i menadžmenta
Veljko J. Marinović (2022)Karstne podzemne vode koristi oko 700 miliona ljudi na svetu, čime je njihov značaj za svetsko stanovništvo nemerljiv. U sklopu doktorske disertacije vršena su istraživanja i analize karstnih sistema dela centralnog Balkana (Srbije, Crne Gore i Savskog sliva Bosne i Hercegovine), kako bi se evaluirao ovaj dragoceni resurs. Analize su vršene na primerima karstnih sistema vrela Perućac, Seljašnica, Mokra i Mlava (Srbija), Oko Bijele i Rijeka Crnojevića (Crna Gora) i vrelo Bosne (Bosna i Hercegovina), kao i na regionalnom ...karstni sistem, podzemna voda, pritisci na kvantitet i kvalitet, menadžment podzemnih vodnih resursaVeljko J. Marinović. Regionalna karakterizacija karstnih podzemnih voda dela centralnog Balkana u funkciji njihovog održivog korišćenja i menadžmenta, Beograd : [V. Marinović], 2022
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Epidotized sanidine in quartzlatites from Grot
Propilitska alteracija je veoma česta u gornjokredno-tercijarnim vulkanitima Srbije. Kvarclatiti Grota, otkriveni na dubini od oko 550 m u jednoj od istražnih bušotina su holokristalaste porfirske strukture sa fenokristalima sanidina dimenzija i do 1,5 x 2 cm. Optičkim ispitivanjima su u kvarclatitu potvrdjeni i elementi sitaste, pojkilitske i glomeroporfirske strukture. Kao fenokristali prisutni su sanidin, plagioklas, kvarc, biotit i amfiboli. Sekundarni minerali su hlorit, epidot, coisit, Fe-hidroksidi, redak kalcit i ilit. U fenokristalima sanidina se zapažaju „lepeze“ izduženih kristala ...Danica Srećković-Batoćanin, Suzana Erić, Nikola Novičić, Nikola Pašajlić, Natalija Batoćanin. "Epidotized sanidine in quartzlatites from Grot" in Book of Abstracts, III Congress of Geologists of Bosnia and Herzegovina with international participation, Neum, 21. – 23.09.2023, Ilidža : Udruženje/udruga geologa u Bosni i Hercegovini (2023)
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Hydrothermal Synthesized and Alkaline Activated Carbons Prepared from Glucose and Fructose—Detailed Characterization and Testing in Heavy Metals and Methylene Blue Removal
Sanja Krstić, Milan Kragović, Maja Pagnacco, Vladimir Dodevski, Branka Kaluđerović, Miloš Momčilović, Ivica Ristović, Marija Stojmenović (2018)glukoza, fruktoza, аktivni ugalj, hidrotermalni tretman, aktivacija hidroksida, teški metali, metilen plavo... treatment. After preparation, samples were characterized in details. Different techniques were used: x-ray powder diffraction analysis, Raman spectral analysis, elemental analysis, and determination of textural and morphological properties. Obtained results showed dependence of investigated properties and ...
... treatment. After preparation, samples were characterized in details. Different techniques were used: x-ray powder diffraction analysis, Raman spectral analysis, elemental analysis, and determination of textural and morphological properties. Obtained results showed dependence of investigated properties and ...
... 3.1.2. Elemental Analysis The contents of organic C, N, O and H in glucose and fructose samples obtained after hydrothermal treatment and activation with different hydroxides were determined by elemental analysis and the results are listed in Table 1. Table 1. Elemental analysis of the glucose and ...Sanja Krstić, Milan Kragović, Maja Pagnacco, Vladimir Dodevski, Branka Kaluđerović, Miloš Momčilović, Ivica Ristović, Marija Stojmenović . "Hydrothermal Synthesized and Alkaline Activated Carbons Prepared from Glucose and Fructose—Detailed Characterization and Testing in Heavy Metals and Methylene Blue Removal" in Minerals, MDPI (2018)
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Asbestos-Based Pottery from Corsica: The First Fiber-Reinforced Ceramic Matrix Composite
Asbestos-containing pottery shards collected in the northeast of Corsica (Cap Corse) and dating from the 19th century, or earlier, have been analyzed by SEM-EDS, XRPD, FTIR and Raman microspectroscopy. Blue (crocidolite) and white (chrysotile) asbestos fiber bundles are observed in cross-sections. Most of the asbestos is partly or totally dehydroxylated, and some transformation to forsterite is observed to occur, indicative of a firing above 800 C. Examination of freshly fractured pieces shows a nonbrittle fracture with fiber pull-out, consistent with ...... amorphous phase formed in the reaction. Furthermore, for this sample, it was not possible to observe the fiber bundles by optical and scanning, electron microscopy, which is most likely due to the higher degree of reaction between phases. Figure 9 compares the spectra recorded from the periphery ...
... surfaces and cross-sections were observed with an optical microscope (BX51 Microscope, Olympus Corporation, Tokyo, Japan). Raman microspectroscopic analysis was performed using, two instruments: (i) a high-resolution HR800 LabRam spectrometer (Horiba Scientific Jobin Yvon, Longjumeau, France) coupled ...
... Jobin Yvon, Lille, France) spectrometer equipped with YAG 532 nm and He 633 nm lasers and a similarly cooled CCD detector (resolution ~4 cm !). The analysis was carried out with Olympus x10, x50 and x100 ultralong, working distance objectives in order to obtain a characterization of the main phases ...Philippe Colomban, Aleksandar Kremenović. "Asbestos-Based Pottery from Corsica: The First Fiber-Reinforced Ceramic Matrix Composite" in Materials, MDPI AG (2020). https://doi.org/10.3390/ma13163597
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Determination of the groundwater-leakage mechanism (binary mixing) in a karstic dam site using thermometry and isotope approach (HPP Visegrad, Bosnia, and Herzegovina)
Earth-Surface Processes,Geology, Pollution, Soil Science, Water Science and Technology, Environmental Chemistry, Global and Planetary ChangeLjiljana Vasić, Saša Milanović, Anita Puskás-Preszner, Laszlo Palcsu. "Determination of the groundwater-leakage mechanism (binary mixing) in a karstic dam site using thermometry and isotope approach (HPP Visegrad, Bosnia, and Herzegovina)" in Environmental Earth Sciences, Springer Science and Business Media LLC (2020). https://doi.org/10.1007/s12665-020-08910-x
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New approach to correlation of hydrocarbon reservoirs in sandstone layers of the "Mokrin" field"
Saša Ivanišević, Dejan Radivojević (2018)геофизички каротаж, депозиционе средине, лежишта угљоводоника, миоцен, пост‐ рифтнo, секвенциона стратиграфија... the quantitative interpretation of well‐log curves and the analysis of geological data from nine wells: KM‐117, 17, 1, 2, 3, 4, 5, 6 and 7 (Figure 1а and 1b). The principles of sequence stratigraphy have been applied in the analysis of geophy‐ sical and geological data, while the correlation ...
... ls. Reconstruction of depositional environments and correlation of lithostratigraphic units (Figure 1a and 1b) have been executed based on the analysis of the shape and characteristics of curves of gamma ray (GR) and specific resistivity (RT) logs. Funnel shape of the GR log points to the ...
... ial” correlation, hydrocarbon reservoirs of the “Mokrin” field represent individual sandstone layers. The new approach, using the analysis of geological and geophysical data according to the principles of sequence stratigraphy, with the focus on definition of depositional environments ...Saša Ivanišević, Dejan Radivojević. "New approach to correlation of hydrocarbon reservoirs in sandstone layers of the "Mokrin" field"" in 17th Serbian Geological Congress, Vrnjačka Banja, 17-20 maj 2018, Srpsko geološko društvo (2018)
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Influence of paleoenvironmental conditions on distribution and relative abundance of saturated and aromatic hydrocarbons in sediments from the NW part of the Toplica basin, Serbia
Nikola Burazer, Aleksandra Šajnović, Nebojša Vasić, Milica Kašanin-Grubin, Dragana Životić, João Graciano Mendonça Filho, Predrag Vulić, Branimir Jovančićević (2020)Nikola Burazer, Aleksandra Šajnović, Nebojša Vasić, Milica Kašanin-Grubin, Dragana Životić, João Graciano Mendonça Filho, Predrag Vulić, Branimir Jovančićević. "Influence of paleoenvironmental conditions on distribution and relative abundance of saturated and aromatic hydrocarbons in sediments from the NW part of the Toplica basin, Serbia" in Marine and Petroleum Geology, Elsevier BV (2020). https://doi.org/10.1016/j.marpetgeo.2020.104252
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Microstructural and magnetic properties of electrospun hematite/cuprospinel composites
Phase composition, microstructural and magnetic properties of electrospun hematite/cuprospinel composites were investigated. Samples were synthesized starting with 0 to 10 mol% of copper relative to iron. The round shape of reference electrospun fbres was preserved upon their heating up to 600 °C in air, whereas at 700 °C hollow substructure was additionally formed. In these reference samples the presence of hematite phase was detected by XRPD. A small amount (traces) of Fe3O4 /γ-Fe2O3 was also found, due to the ...Electrical and Electronic Engineering, Condensed Matter Physics, Atomic and Molecular Physics and Optics, Electronic, Optical and Magnetic MaterialsMira Ristić, Aleksandar Kremenović, Michael Reissner, Željka Petrović, Svetozar Musić. "Microstructural and magnetic properties of electrospun hematite/cuprospinel composites" in Journal of Materials Science: Materials in Electronics, Springer Science and Business Media LLC (2020). https://doi.org/10.1007/s10854-020-03526-0
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Classification of Terms on a Positive-Negative Feelings Polarity Scale Based on Emoticons
Mihailo Škorić (2017)The goal of this paper is to draw attention to the possibility of using emoticon-riddled text on the web in language-neutral sentiment analysis. It introduces several innovations in the existing framework of research and tests their effectiveness. It also presents a software tool especially made for that purpose, explains how it builds a database with sentimental value of terms and offers the user manual. Finally, it presents a software tool that tests the new database and gives some examples ...... according to the mood that is expressed in them to help find the necessary information. – Natural language understanding and analysis: understanding of written text and text queries, analysis of moods in the text, processing of digital linguistic resources such as automatic parallelization and automation of ...
... ABSTRACT: The goal of this paper is to draw attention to the possibility of using emoticon-riddled text on the web in language- neutral sentiment analysis. It introduces sev- eral innovations in the existing framework of research and tests their effectiveness. It also presents a software tool especially ...
... sentimental value of terms and offers the user manual. Finally, it presents a software tool that tests the new database and gives some examples of the analysis of the ob- tained results. KEYWORDS: data mining, information extraction, emotions, text on the web. PAPER SUBMITTED: 24 January 2017 PAPER ACCEPTED: ...Mihailo Škorić. "Classification of Terms on a Positive-Negative Feelings Polarity Scale Based on Emoticons" in Infotheca, Faculty of Philology, University of Belgrade (2017). https://doi.org/10.18485/infotheca.2017.17.1.4
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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...... measuring particle size and calculating redispersibility index, as well as by solid-state analysis (by differential scanning calorimetry and X-ray powder diffraction) and visualization of morphology (by scanning electron microscopy and polarized light microscopy). Finally, the extent of interactions between ...
... sample holder to minimize background. Results were analyzed using PDXL2 (v. 2.8.30) integrated X-ray powder diffraction software. 2.7. Scanning electron microscopy (SEM) The morphology of the lyophilzates was analyzed by scanning elec- tron microscopy (SEM). A small amount of the sample was placed ...
... with the nanoparticles, while the crystalline bulking agent is providing the cake structure (Jena et al., 2016). 3.4. Morphology Scanning electron microscopy (SEM) was used to examine the morphology of the lyophilizates. The images are shown in Figs. 4, 5, and S2. In the sample of freeze-dried ...Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557