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2421 items
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3D modeling and monitoring of karst system as a base for its evaluation and utilization: a case study from eastern Serbia
Earth-Surface Processes, Geology, Pollution, Soil Science, Water Science and Technology, Environmental Chemistry, Global and Planetary ChangeSaša Milanović, Zoran Stevanović, Ljiljana Vasić, Vesna Ristić-Vakanjac. "3D modeling and monitoring of karst system as a base for its evaluation and utilization: a case study from eastern Serbia" in Environmental Earth Sciences, Springer Science and Business Media LLC (2013). https://doi.org/10.1007/s12665-013-2591-9
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INVENTS: A Hybrid Mine Ventilation Planning and Design System
Ventilation system analysis is a complex process based on the calculation and analysis of numerous parameters. These problems can be successfully solved by the SimVent numerical package, but a full understanding and use of the obtained results require the involvement of an experienced specialist in the ventilation field. The solution was found in the creation of a hybrid system INVENTS, whose knowledge base represents a formalization of the expert knowledge in the mine ventilation field. In this paper we ...... fully exploits the GUI (graphical user interface) technology available for MS Windows applications. It enables a straightforward and easy manipulation of input data and control over parts of the problem-solving process. It also offers suggestions and recommendations to the user for the improvement of ...
... The novel approach uses all possibilities offered by computer hardware and software that are at the disposition of mine engineers. Software packages for mine ventilation simulation obtained a key role in the process of mine ventilation planing and design. Ventilation design is just one element or phase ...
... estimation ventilation simulation Design CFD Estimates estimation of gas and dust emission and temperature conditions flow process modelling using CFD Data acquis ition ventilation and psychrometric parameters ventilation and psychrometric parameters Fig. 3. Architecture of the hybrid system INVENTS ...Lilić Nikola, Stanković Ranka, Obradović Ivan. "INVENTS: A Hybrid Mine Ventilation Planning and Design System" in Proceedings of International Scientific Conference of FME Session 4: Automation Control and Applied Informatics , Hong Kong : iConcept Press (2013)
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INVENTS: a hybrid system for subsurface ventilation analysis
Ventilation system analysis is a complex process based on the calculation and analysis of numerous parameters. These problems can be successfully solved by the SimVent numerical package, but a full understanding and use of the obtained results require the involvement of an experienced specialist in the ventilation field. The solution was found in the creation of a hybrid system INVENTS, whose knowledge base represents a formalization of the expert knowledge in the mine ventilation field. In this paper we ...... fully exploits the GUI (graphical user interface) technology available for MS Windows applications. It enables a straightforward and easy manipulation of input data and control over parts of the problem-solving process. It also offers suggestions and recommendations to the user for the improvement of ...
... The novel approach uses all possibilities offered by computer hardware and software that are at the disposition of mine engineers. Software packages for mine ventilation simulation obtained a key role in the process of mine ventilation planing and design. Ventilation design is just one element or phase ...
... estimation ventilation simulation Design CFD Estimates estimation of gas and dust emission and temperature conditions flow process modelling using CFD Data acquis ition ventilation and psychrometric parameters ventilation and psychrometric parameters Fig. 3. Architecture of the hybrid system INVENTS ...Nikola Lilić, Ranka Stanković, Ivan Obradović. "INVENTS: a hybrid system for subsurface ventilation analysis" in Proc. of International Scientific Conference of FME, September 2000, Ostrava, FME (2000)
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A Multilingual Evaluation Dataset for Monolingual Word Sense Alignment
Sina Ahmadi, John P McCrae, Sanni Nimb, Fahad Khan, Monica Monachini, Bolette S Pedersen, Thierry Declerck, Tanja Wissik, Andrea Bellandi, Irene Pisani, [...] Ranka Stanković and others (2020)Aligning senses across resources and languages is a challenging task with beneficial applications in the field of natural language processing and electronic lexicography. In this paper, we describe our efforts in manually aligning monolingual dictionaries. The alignment is carried out at sense-level for various resources in 15 languages. Moreover, senses are annotated with possible semantic relationships such as broadness, narrowness, relatedness, and equivalence. In comparison to previous datasets for this task, this dataset covers a wide range of languages ...... information ex- traction and building of lexical semantic resources for NLP applications. Henrich, V., Hinrichs, E., and Vodolazova, T. (2011). Semi-automatic extension of GermaNet with sense defi- nitions from Wiktionary. In Proceedings of the 5th Lan- guage and Technology Conference (LTC 2011), ...
... bd. 1-6, volume 1-6. Gyldendal. https://ordnet.dk/ddo en. Fellbaum, C. (2010). WordNet. In Theory and applica- tions of ontology: computer applications, pages 231– 243. Springer. Gantar, P. and Krek, S. (2011). Slovene lexical database. In Natural language processing, multilinguality, pages 72–80 ...
... Communication Departmental Papers. Philadelphia. Krstev, C., Palović-Lažetić, G., Vitas, D., and Obradović, I. (2004). Using textual and lexical resources in developing Serbian Wordnet. SCIENCE AND TECHNOLOGY, 7(1- 2):147–161. Kwong, O. Y. (1998). Aligning WordNet with additional lexical resources ...Sina Ahmadi, John P McCrae, Sanni Nimb, Fahad Khan, Monica Monachini, Bolette S Pedersen, Thierry Declerck, Tanja Wissik, Andrea Bellandi, Irene Pisani, [...] Ranka Stanković and others . "A Multilingual Evaluation Dataset for Monolingual Word Sense Alignment" in Proceedings of the 12th Conference on Language Resources and Evaluation (LREC 2020), Marseille, European Language Resources Association (ELRA) (2020)
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Vebran Web Services for Corpus Query Expansion
Ranka Stanković, Miloš Utvić (2020)U ovom radu se govori o razvoju veb usluga Vebran i njihovoj primeni u poboljšanju pretraživanja korpusa. Veb-servisi Vebran koriste se za konsultovanje spoljnih leksičkih izvora za srpski jezik (uglavnom elektronski morfološki rečnici i srpski Vordnet) i proširivanje korisničkih upita radi dobijanja relevantnijih rezultata iz srpskih korpusa.... Serbian — Automata, Text and Electronic Dictionaries. Belgrade: Faculty of Philology, 2008 Krstev, Cvetana, Gordana Pavlović-Lažetić and Ivan Obradović. “Using Tex- tual and Lexical Resources in Developing Serbian Wordnet”. Romanian Journal of Information Science and Technology Vol. 7, no. 1–2 (2004): ...
... the authorized users and applications. Further improvement of web services will include better support for multi-word units and a more flexible combination of different query parameters. Acknowledgment This research was partly supported by the Ministry of Education, Science and Technological Development ...
... expressions and graphs of automata and transducers for searching and extraction; and 4) Build cascades of rules. Corpora SrpKor2013 (cf. 2.1) and RudKor (cf. 2.2) can be searched by OCWB, while a search of RudKor is also available through NoSketch Engine. This paper presents the process of upgrading ...Ranka Stanković, Miloš Utvić. "Vebran Web Services for Corpus Query Expansion" in Infotheca, Faculty of Philology, University of Belgrade (2020). https://doi.org/10.18485/infotheca.2019.19.2.5
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Advancing Sentiment Analysis in Serbian Literature: A Zero and Few-Shot Learning Approach Using the Mistral Model
Ova studija predstavlja analizu sentimenta srpskih starih romana iz perioda 1840-1920, koristeći veliki jezički model (LLM) Mistral za tehniku učenja sa zasnovani na takozvanim "zero" i "few-shot" pokušajima. Glavni pristup uvodi inovacije osmišljavanjem istraživačkih upita (promptova) uključuju tekst sa uputstvom za klasifikaciju bez primera i na osnovu nekoliko primera, omogućavajući jezičkom modelu da klasifikuje osećanja u pozitivne, negativne ili objektivne kategorije. Ova metodologija ima za cilj da pojednostavi analizu osećanja ograničavanjem odgovora, čime se povećava preciznost ...Milica Ikonić Nešić, Saša Petalinkar, Mihailo Škorić, Ranka Stanković, Biljana Rujević. "Advancing Sentiment Analysis in Serbian Literature: A Zero and Few-Shot Learning Approach Using the Mistral Model" in In Proceedings of the Sixth International Conference on Computational Linguistics in Bulgaria (CLIB 2024), BAS (2024)
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Actual contamination of the Danube and Sava rivers at Belgrade (2013)
Milan Antonijević, Marija Arsović, Josef Cáslavský, Vesna Cvetković, Predrag Dabić, Mladen Franko, Gordana Ilić, Milena Ivanovic, Nevena Ivanović, Milica Kosovac, Dragana Medić, Slobodan Najdanović, Milica Nikolić, Jovana Novaković, Tatjana Radovanović, Djurdjina Ranić, Bojan Šajatović, Gorica Špijunović, Ivana Stankov, Jelena Tošović, Polonca Trebse, Olivera Vasiljević, Jan Schwarzbauer (2014)rečni sistemi, stanje zagađenja, organski zagađivači, teški metali, skrining analize, non-target screening... VASILJEVIĆ2 and JAN SCHWARZBAUER9* 1School of Science, University of Greenwich, England, UK, 2High Business-Technical School, Užice, Serbia, 3Faculty of Chemistry, Brno University of Technology, Czech Republic, 4Faculty of Technology and Metallurgy, Faculty of Chemistry, Faculty of Mining and Geology ...
... measured after 30 min of exposure and the inhibition of luminescence with 95 % confidence limits, according to ISO 11348-2, was calculated, using a model supported by computer software. The whole process was completed in accurate time intervals provided by machine and computer signal- ization. The blank test ...
... POLONCA TREBŠE 5 , ОЛИВЕРА ВАСИЉЕВИЋ 2 и JAN SCHWARZBAUER 9 1 School of Science, University of Greenwich, England, UK, 2Висока пословно–техничка школа, Ужице, 3 Faculty of Chemistry, Brno University of Technology, Czech Republic, 4Технолошко–металуршки факултет, Хемијски факултет, Рудар ...Milan Antonijević, Marija Arsović, Josef Cáslavský, Vesna Cvetković, Predrag Dabić, Mladen Franko, Gordana Ilić, Milena Ivanovic, Nevena Ivanović, Milica Kosovac, Dragana Medić, Slobodan Najdanović, Milica Nikolić, Jovana Novaković, Tatjana Radovanović, Djurdjina Ranić, Bojan Šajatović, Gorica Špijunović, Ivana Stankov, Jelena Tošović, Polonca Trebse, Olivera Vasiljević, Jan Schwarzbauer. "Actual contamination of the Danube and Sava rivers at Belgrade (2013)" in Journal of the Serbian Chemical Society, National Library of Serbia (2014). https://doi.org/10.2298/JSC131105014A
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Mineral Resources of Serbia: Environmental, Societal and Economic Challenges
... Editor: Igor Janev O 2019 Nova Science Publishers, Inc. Chapter 10 EMERGING POLLUTANTS IN SERBIA: ENVIRONMENTAL, SOCIALAND ECONOMIC FACTS, ISSUES AND CHALLENGES Jelena Milić" and Tatjana Šolević Knudsen Center of Chemistry, Institute of Chemistry, Technology and Metallurgy, University of Belgrade ...
... Glycerol Market.” European Journal of Lipid Science and Technology 116 (10): 1432—39. doi:10.1002/ejlt.201400229. Crocker, M, ed. 2010. 7hermochemical Conversion of Biomass to Liquid Fuels and Chemicals. Cambridge, UK: Royal Society of Chemistry. “Crop Farming from 2005. The Statistical Office ...
... PhD, Faculty of Science and Mathematics, Department of Chemistry, University of Nis, Serbia BIOGRAPHICAL SKETCHES Nataša Đurišić-Mladenović, PhD Affiliation: University of Novi Sad, Faculty of Technology Novi Sad, Serbia Contact: natasadjm(tf.uns.ac.rs Education: PhD and MSc in Chemical ...Vladimir Simić, Rade Jelenković, Dragana Životić. "Mineral Resources of Serbia: Environmental, Societal and Economic Challenges" in Serbia: Current Issues and Challenges in the Areas of Natural Resources, Agriculture and Environment,, Nova Science Publishers, Inc. (2019)
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Groundwater resources for drinking water supply in Serbia´s Southeast Pannonian basin
Dušan Polomčić, Bojan Hajdin, Marina Ćuk, Petar Papić, Zoran Stevanović. "Groundwater resources for drinking water supply in Serbia´s Southeast Pannonian basin" in Carpathian Journal of Earth and Environmental Sciences (2014)
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BaTiO3/NixZn1−xFe2O4 (x = 0, 0.5, 1) Composites Synthesized by Thermal Decomposition: Magnetic, Dielectric and Ferroelectric Properties
Marija Šuljagić, Ivan Petronijević, Miljana M. Mirković, Aleksandar Kremenović, Adis Džunuzović, Vladimir B. Pavlović, Aleksandra Kalezić-Glišović, Ljubica Andjelković (2023)To investigate the influence of spinel structure and sintering temperature on the functional properties of BaTiO3/NixZn1−xFe2O4 (x = 0, 0.5, 1), NiFe2O4, ZnFe2O4, and Ni0.5Zn0.5Fe2O4 were in situ prepared by thermal decomposition onto BaTiO3 surface from acetylacetonate precursors. As-prepared powders were additionally sintered at 1150 °C and 1300 °C. X-ray powder diffraction (XRPD) and scanning electron microscopy (SEM) coupled with electron dispersive spectroscopy (EDS) were used for the detailed examination of phase composition and morphology. The magnetic, dielectric, and ...ferroelectric, dielectric properties, magnetic properties, titanate/ferrite composites, phase composition... access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:/ / creativecommons.org//licenses/by/ 4.0/). Department of Chemistry, University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrrade, ...
... c effect: Principles and applications in biology and medicine—A review. Mater. Today Bio 2021, 12, 100149. [CrossRef] 16. Cai,T.-Y.; Liu,S.-C.;Ju,S.; Liu, C.-Y.; Guo, G.-Y. Multiferroic Double Perovskites ScFe; _„CrOy (1/6 < x < 5/6) for Highly Efficient Photovoltaics and Spintronics. Phys. Rev ...
... Hossain, S. Magnetic and Optical Characterization of Cobalt Ferrite-Barium Titanate Core-Shell for Biomedical Applications. IEEE Trans. Magn. 2022, 58, 2501208. [CrossRef] Sreenivasulu, G.; Qu, H.; Srinivasan, G. Multiferroic oxide composites: Synthesis, characterisation and applications. Mater. Sci. ...Marija Šuljagić, Ivan Petronijević, Miljana M. Mirković, Aleksandar Kremenović, Adis Džunuzović, Vladimir B. Pavlović, Aleksandra Kalezić-Glišović, Ljubica Andjelković. "BaTiO3/NixZn1−xFe2O4 (x = 0, 0.5, 1) Composites Synthesized by Thermal Decomposition: Magnetic, Dielectric and Ferroelectric Properties" in Inorganics, MDPI AG (2023). https://doi.org/10.3390/inorganics11020051
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The subthermal potential of karstic groundwater of Kučaj–Beljanica region in Serbia estimated by the multivariate analysis
Earth-Surface Processes, Geology, Pollution, Soil Science, Water Science and Technology, Environmental Chemistry, Global and Planetary ChangeLjiljana Vasić, Dragana Ž. Živojinovic, Vladana Rajaković-Ognjanović, Huang Fen, Cao Jianhua. "The subthermal potential of karstic groundwater of Kučaj–Beljanica region in Serbia estimated by the multivariate analysis" in Environmental Earth Sciences, Springer Science and Business Media LLC (2021). https://doi.org/10.1007/s12665-021-09392-1
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Contribution to the geotechnical classification of municipal waste landfills in Serbia
Management, Monitoring, Policy and Law, Nature and Landscape Conservation, Geochemistry and Petrology, Waste Management and Disposal,Geotechnical Engineering and Engineering Geology,Water Science and Technology,Environmental Chemistry,Environmental EngineeringDragoslav Rakić, Irena Basarić, Laslo Čaki, Slobodan Ćorić. "Contribution to the geotechnical classification of municipal waste landfills in Serbia" in Environmental Geotechnics, Thomas Telford Ltd. (2018). https://doi.org/10.1680/jenge.18.00028
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Formative evaluation of e-learning projects with the logical framework approach
... dynamic that characterizes educational systems in the 21st century, resulting from the merge of different disciplines, such as computer science, communication technology, and pedagogy, since majority of the definitions contained characteristics of more than one discipline [15]. The definitions existing ...
... significant parts of a learning value chain, including management and delivery [17]. E-Learning supports the educational processes utilizing information and communications technology to mediate synchronous as well as asynchronous learning and teaching activities” [18]. Despite the large amount of ...
... evaluation that applicants were required to develop and submit within the mentioned Call. Baektel is an innovative project, the technology platform is implemented on an experimental basis, and is not relevant the analysis of training needs and the courses to be activated, rather the analysis of ...Roberto Linzalone, Giovani Schiuma, Ivan Obradović, Ranka Stanković. "Formative evaluation of e-learning projects with the logical framework approach" in The Sixth International Conference on e-Learning (eLearning-2015), September 2015, Belgrade, Serbia, Belgrade Metropolitan Univesity (2015)
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E-Connecting Balkan Languages
In this paper we present a versatile language processing tool that can be successfully used for many Balkan languages. This tool relies for its work on several sophisticated textual and lexical resources that were developed for most of Balkan languages. These resources are based on several de facto standards in natural language processing.... Information Science and Technology. Bucureşti: Publishing house of the Romanian academy, Vol. 7, No.1-2, 2004. [21] D. Tufiş, S. Koeva, T. Erjavec, M. Gavrilidou, and C. Krstev. Building Language Resources and Translation Models for Machine Translation focused on South Slavic and Balkan Languages ...
... Improvement of Queries using a Rule Based Procedure for Inflection of Compounds and Phrases. Polibits (37) 2008, Special section: Natural Langugage Processing, Journal of Research and Developement in Computer Science and Engeneering, ed. Grigori Sidorov, Centro Innovacion y Desarrollo Tecnologico ...
... wordnet, so-called Princeton Wordnet (PWN), having today approximately 140,000 synsets. Due to its remarkable size and successful inclusion in various computer-based applications it is considered as a de facto standard upon which wordnets for many other languages were built. One successful a ...Cvetana Krstev, Ranka Stanković, Duško Vitas, Svetla Koeva. "E-Connecting Balkan Languages" in Proceedings of the Workshop Workshop on Multilingual resources, technologies and evaluation for Central and Eastern European Languages, 17 September 2009, eds. C. Vertan, S. Piperidis, E. Paskaleva and Milena Slavcheva, Borovets, Bulgaria : Association for Computational Linguistics Stroudsburg, PA, USA (2009)
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Social-Emo.Sr: Emotional Multi-Label Categorization of Conversational Messages from Social Networks X and Reddit
U digitalnom okruženju južnoslovenskih jezika, analiza emocija u tekstovima na društvenim mrežama postaje sve važnija za razumevanje javnog mnjenja, kreiranje personalizovanog sadržaja i analizu međusobnih interakcija korisnika. U okviru ovog rada predstavljamo detaljnu metodologiju i rezultate označavanja korpusa na srpskom jeziku prema Plutčikovom modelu kategorizacije, koji prepoznaje osam osnovnih emocionalnih kategorija, kao što su radost, tuga, bes, strah, poverenje, gađenje, iščekivanje i iznenađenje. Cilj istraživanja je da se analizira emocionalni sadržaj tekstova preuzetih sa društvenih mreža X (nekada Twitter) ...Milena Šošić, Ranka Stanković, Jelena Graovac. "Social-Emo.Sr: Emotional Multi-Label Categorization of Conversational Messages from Social Networks X and Reddit" in South Slavic Languages in the Digital Environment JuDig Book of Abstracts, University of Belgrade - Faculty of Philology, Serbia, November 21-23, 2024., University of Belgrade - Faculty of Philology (2024)
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Flotability of chalcopyrite from the Rudnik deposit
Директно селективно флотирање олова, бакра и цинка у флотацији рудника „Рудник” датира од 1984. године. Технолошка шема омогућава директно издвајање селективних концентрата у три циклуса. У првом циклусу се издваја минерал олова (галенит), док су минерал бакра (халкопирит) и минерал цинка (марматит) депримирани. У другом циклусу се оток концентрације минерала олова кондиционира и припрема за издвајање минерала бакра. Након кондиционирања, у овом циклусу се издваја минерал бакра. У трећем циклусу се оток концентрације минерала бакра кондиционира и припрема за ...Đurica Nikšić, Predrag Lazić, Milena Kostović. "Flotability of chalcopyrite from the Rudnik deposit" in Journal of Mining Science, Springer Verlag (2021). https://doi.org/10.1134/S1062739121030170
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Coupling of artificial intelligence methods in the development of hybrid intelligent systems
In this paper we present an approach which couples various artificial intelligence (AI) methods in the solution of complex problems that cannot adequately be solved by a single AI method. We argue that the resulting, hybrid intelligent systems (HIS) can be successfully implemented with the use of available AI software libraries. Different coupling methods are analyzed and a classification of hybrid systems based on the chosen method is given. Two case studies of hybrid systems used in mining engineering ...hibridni inteligentni sistemi, spregnuti sistemi, metode veštačke inteligencije, rudarske primene veštačke inteligencije... conventional computer systems: database applications, spreadsheet applications, GIS environment, CAD/CAM, etc., with the ability to interchange data with different processes using different media. 3. A hybrid system for mine ventilation planing and analysis Ventilation planing and analysis is ...
... or more AI methods, but also by integrating AI methods and conventional computer systems, such as database or spreadsheet applications. In this paper we present two hybrid intelligent systems which couple expert systems, neural networks and genetic algorithms in order to solve some complex problems ...
... Estimates estimation of gas and dust emission and temperature conditions flow process modelling using CFD Data acquisition ventilation and psychrometric parameters ventilation and psychrometric parameters Fig. 2 Structure of the hybrid system for mine ventilation planing and analysis INVENTS consists ...Ranka Stanković, Ivan Obradović, Nikola Lilić. "Coupling of artificial intelligence methods in the development of hybrid intelligent systems" in X Kongres Matematičara, Matematički fakultet, Beograd (2001)
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Crystal structure of K3EuSi2O7
alkalni silikati elemenata retkih zemalja, kristalna struktura, sinteza metodom fluksa, rendgenska difrakcija na monokristalu... REFERENCES 1. J. Felsche, In The Crystal Chemistry of the Rare-Earth Silicates. Rare Earths. Structure and Bonding, Vol. 13, Heidelberg: Springer, Berlin, Germany, 1973 (https://doi.org/10.1007/3-540-06125-8_3) 2. A. Kitai, In Luminescent Materials and Applications, John Wiley & Sons Ltd., Chichester ...
... the Ministry of Education, Science and Technological Development of the Republic of Serbia (Grant No. III45007 and III45015); Ministry of Education, Science and Technological Development of the Republic of Serbia & Austria Federal Ministry of Education, Science and Research (project No. 451- ...
... of optical and magnetic properties combined with high thermal stability.1‒9 All this makes them very interesting and promising materials for different applications. REE silicates also exhibit a broad structural diversity.10 A highly adaptive framework can incorporate almost all REEs and this opens ...Sabina Kovač, Predrag Dabić, Aleksandar Kremenović. "Crystal structure of K3EuSi2O7" in Journal of the Serbian Chemical Society, National Library of Serbia (2021). https://doi.org/10.2298/JSC210218026K
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Mitigating hydrate formation in onshore gas wells: A case study on optimization techniques and prevention
Gas wells, particularly those situated onshore, play a vital role in the global energy sector by supplying a significant portion of natural gas. However, operational challenges, notably gas hydrate formation, pose substantial issues, leading to complications such as flowline blockages and unexpected well shutdowns. Gas hydrates, crystalline structures resembling ice, ...Gas Well, Gas Hydrate Formation, Well Modeling, Well Performance Optimization, Choke Position Adjustments, Methanol InjectionMilica Ješić, Bojan Martinović, Stefan Stančić, Miroslav Crnogorac, Dušan Danilović. "Mitigating hydrate formation in onshore gas wells: A case study on optimization techniques and prevention" in Underground Mining Engineering, Beograd : Rudarsko-geološki fakultet (2023)
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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2023)Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one). In the current study, the freeze-drying process (formulation and process parameters) was investigated to improve the storage stability of the previously developed formulation. Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while formulations were freeze-dried under two conditions (primary drying at -10 or -45 °C). The obtained lyophilizates were characterized in terms ...... MH096463 to JC) and National Science Foundation, Division of Chemistry (CHE- 1625735 to JC). The authors would also like to thank Mr. Klaus Weyhing, Department of Pharmaceutical Technology at Uni- versity of Tubingen and dr Vladimir Dobričić, Department of Pharma- ceutical Chemistry, University of ...
... In the current study, the freeze-drying process (formulation and Š:ŽŽŽŽng process parameters) was investigated to improve the storage stability of the previously developed formulation. Trehalose Different combinations of lyoprotectant (sucrose or trehalose) and bulking agent (mannitol) were varied while ...
... freeze-dried products depends on the process and formulation parameters, including the choice of cry- o/lyoprotectant and its concentration (Jakubowska et al., 2022; Beir- owski et al., 2011). Furthermore, bulking agents can be added to increase mechanical strength and ensure an attractive appearance ...Jelena R. Mitrović, Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović, Pegi Ahlin Grabnar, Odon Planinšek, Dominique Lunter, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study" in European Journal of Pharmaceutical Sciences, Elsevier BV (2023). https://doi.org/10.1016/j.ejps.2023.106557