Претрага
518 items
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Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach
Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić (2021)Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric ...... sample holder was used. The XRPD data were treated by the PDXL2 integrated X-ray powder diffraction software (v. 2.8.30; Rigaku Corporation, Tokyo, Japan). Dissolution Study For the dissolution study, the direct dialysis bag method was used. Dialysis bag (cellulose membrane MW cut-off 12000, Sigma-Aldrich ...
... nanosuspension by wet media milling. Int. J. Pharm. 2018, 540, 150–161. [CrossRef] 24. Yang, H.; Teng, F.; Wang, P.; Tian, B.; Lin, X.; Hu, X.; Zhang, L.; Zhang, K.; Zhang, Y.; Tang, X. Investigation of a nanosuspension stabilized by Soluplus®to improve bioavailability. Int. J. Pharm. 2014, 477, 88–95. [CrossRef] ...
... DK-I-60-3 in the eluates was determined by LC-MS/MS method. From the concentration data, the pharmacokinetic parameters were calculated by “PK Functions for Microsoft Excel” (https://www.pharmpk.com/soft.html, accessed on 1 June 2021). 2.2.5. Analytical Method For the determination of DK-I-60-3 in all experiments ...Jelena R. Mitrović , Branka Divović-Matović, Daniel E. Knutson, Jelena B. Ðoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić. "Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach" in Pharmaceutics, MDPI, Basel, Switzerland (2021). https://doi.org/10.3390/pharmaceutics13081188
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Primena termografije u rudarstvu
Stevan Đenadić, Vesna Damnjanović, Predrag Jovančić, Dragan Ignjatović, Dragutin Jovković, Filip Miletić (2019)Danas, gotovo da nema oblasti u nauci i tehnici u kojoj se Infracrvena termografija ne primenjuje kao metoda za lociranje i praćenje zagrejanih objekata ili tela, beskontaktnu procenu temperature površina, i nedestruktivno ispitivanje materijala. U radu su prikazane mogućnosti i perspektive primene ove metode u oblasti rudarstva.... Infrared thermography is not used as a method for locating and monitoring heated objects or bodies, contactless surface temperature estimation and non-destructive material testing. This paper presents the possibilities and prospects of applying this method in the field of mining. Key words: ...
... Literatura [1] Gaussorgues G., Infrared Thermography. English language edition, Berlin, Germany: Springer-Science+Busness Media,1994. [2] Maldague X. P. V., Active Thermography in Nondestructive evaluation of materials by infrared thermography, New York, USA: John Wiley & Sons, 2001. 65 ...
... Mechanical Components. URL:https://www.infratec-infrared.com/thermography/industries- applications/maintenance-of-mechanical-assemblies/ [10] Zhai X., Wu S., Wnag K., Drebenstedt C., Zhao J., Environmental influences and extinguish technology of spontaneous combustion of coal gangue heap of Baijigou ...Stevan Đenadić, Vesna Damnjanović, Predrag Jovančić, Dragan Ignjatović, Dragutin Jovković, Filip Miletić. "Primena termografije u rudarstvu" in IX Međunarodna konferencija UGALJ 2019, Zlatibor, Srbija, 23-26. oktobar 2019., Jugoslovenski komitet za površinsku eksploataciju (2019)
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Indeksi kontrole održavanja i korišćenja rotornog bagera
Razvoj površinske eksploatacije se u velikom stepenu zasniva na svestranoj mehanizaciji rudarskih radova. Kako bi se zadovoljili potrebni kapaciteti, neophodna je primena savremene mehanizacije, velikih kapaciteta i pouzdanosti u radu. Naime, sa stepenom povećanja mehanizovanosti radova smanjuje se broj zaposlenih radnika, povećava produktivnost rada, smanjuju troškovi po jedinici proizvoda, a samim tim i povećava ekonomičnost površinske eksploatacije. Predmet istraživanja su rotorni bageri SRs 1200 koji predstavljaju samohodne mašine kontinuiranog dejstva namenjene za otkopavanje jalovine i korisne supstance na površinskim ...Jovana Mitrović, Predrag Jovančić, Dragan Ignjatović, Stevan Đenadić, Filip Miletić. "Indeksi kontrole održavanja i korišćenja rotornog bagera" in XI Međunarodna konferencija "Ugalj i kritični minerali 2023", CCM 2023, Zlatibor, 11-14. oktobar 2023., Beograd : Jugoslovenski komitet za površinsku eksploataciju (2023)
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Trans-Lithospheric Diapirism as a Possible Mechanism for Ophiolite Emplacement?
Nikola Stanković, Taras Gerya, Vladica Cvetković, Vesna Cvetkov. "Trans-Lithospheric Diapirism as a Possible Mechanism for Ophiolite Emplacement?" in EGU General Assembly 2024, Vienna, 14-19 April 2024, Göttingen : Copernicus GmbH (2024). https://doi.org/10.5194/egusphere-egu24-568
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Cytotoxic activity of tetradentate Schiff Base Copper(II) complexes
Istraživanje kompleksa bakra kao potencijalnih antikancerogenih agenasa nudi ohrabrujuće perspektive u odnosu na komplekse platine (II) računajući na smanjenu toksičnost, novi mehanizam delovanja, različit spektar aktivnosti i perspektivu neunakrsne rezistencije. Kompleksi Šifovih baza bakra(II) koji sadrže tetradentatne ligande acac2en tipa (acac2en (1); tfacac2en (3), acactfacacen (4), acacphacacen (6)) pokazali su važnu antioksidativnu aktivnost, visok potencijal za interakciju sa HSA i DNK, u prethodnim studijama. Zbog toga je bilo interesantno ispitati i uporediti potencijal antikancerogene aktivnosti in vitro, u odnosu ...Nevenka Gligorijević, Aleksandar Mijatović, Sandra Aranđelović, Rada Baošić . "Cytotoxic activity of tetradentate Schiff Base Copper(II) complexes" in The European Association for Cancer Research 2021 , eacr2021.org/sponsorship (2021)
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Synthesis, characterization and photocatalytic examination of Co0.9Ho0.1MoO4 nanopowders
Milena Rosić, Maja Milošević, Maria Čebela, Vladimir Dodevski, Vesna Lojpur, Radomir Ljupković, Aleksandra Zarubica (2023)... procedure (GNP). The synthesized samples were investigated by DTA, X-ray diffraction (KRD), Fourier transform infrared (FT-IR) spectra, Spectroscopy, Field emission scanning electron microscopy (FESEM), and nitrogen adsorption method. The photocatalytic activity of acquired Cop.Hop , MoO, nanopowders ...
... nanopowders was estimated by the photocatalytic degradation of crystal violet in aqueous solution. A simple and effective . method for controlling: the composition and morphology of Cop.Hoo,, MoOu is presented in this paper, as well as a potentially new approach in the methodology of inorganic synthesis ...Milena Rosić, Maja Milošević, Maria Čebela, Vladimir Dodevski, Vesna Lojpur, Radomir Ljupković, Aleksandra Zarubica. "Synthesis, characterization and photocatalytic examination of Co0.9Ho0.1MoO4 nanopowders" in Programme and the book of abstracts 7th Conference of The Serbian Society for Ceramic Materials 7CSCS-2023, June 14-16, 2023 Belgrade, Serbia , Beograd : Institut za multidisciplinarna istraživanja (2023)
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Numerical modelling of the roughly simultaneous emplacement of two distinct ophiolite belts
Nikola Stanković, Vesna Cvetkov, Vladica Cvetković. "Numerical modelling of the roughly simultaneous emplacement of two distinct ophiolite belts" in 5th Congress Geologists of the Republic of North Macedonia, Ohrid, 28-29. 10. 2024, Македонско геолошко друштво (2024)
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Temperature induced evolution of nanostructured Ni0.9Zn0.1O
Kremenović Aleksandar, Antić Bratislav, Vučinić-Vasić Milica, Colomban Philippe, Jovalekić Čedomir, Bibić Nataša, Kahlenberg Volker, Leoni Matteo (2010)The crystal structure and microstructure of as-prepared and annealed Ni0.9Zn0.1O were refined at room temperature in both the Fm (3) over barm and R (3) over barm space groups. It is shown that below the Neel point (458 K), where magnetic ordering triggers the presence of a trigonal strain, the common usage of a higher-symmetry non-admissible space group for crystal structure and microstructure analysis via the Rietveld method may result in both an incorrect structure description and incorrect microstructure ...Kremenović Aleksandar, Antić Bratislav, Vučinić-Vasić Milica, Colomban Philippe, Jovalekić Čedomir, Bibić Nataša, Kahlenberg Volker, Leoni Matteo. "Temperature induced evolution of nanostructured Ni0.9Zn0.1O" in Journal of Applied Crystallography no. 43, Denmark: Blackwell Munksgaard (2010). https://doi.org/10.1107/S0021889810019163
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Solid state synthesis of extra phase-pure Li4Ti5O12 spinel
Фазно чист спинел Li4Ti5O12 са величином честица мањом од 500 nm добијен је реакцијом у чврстом стању из стехиометријске смеше наноанатаса (ТiО2) и Li2CO3 која је претходно активирана механохемијским поступком. Реакција у чврстом стању у потпуности се завршава за само 4 часа на температури од 800 ºC. Уз помоћ XRPD, SEM и TG/DSC анализе испитане су структурне и микроструктурне карактеристике добијеног спинела, механизам реакције између анатаса и Li2CO3, као и термичка стабилност Li4Ti5O12. Реакција започиње разлагањем Li2CO3 на температурама ...дифракција рендгенских зрака, механизам реакције, термичка стабилност, Li4Ti5O12, спинел, фазно чист узоракIvana Veljković, Dejan Poleti, Ljiljana Karanović, Miodrag Zdujić, Goran Branković. "Solid state synthesis of extra phase-pure Li4Ti5O12 spinel" in Science of Sintering, National Library of Serbia (2011). https://doi.org/10.2298/SOS1103343V
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Resource-based WordNet Augmentation and Enrichment
In this paper we present an approach to support production of synsets for SerbianWordNet(SerWN)byadjustingPrincetonWordNet(PWN)synsetsusing several bilingual English-Serbian resources. PWN synset definitions were automatically translated and post-edited, if needed, while candidate literals for Serbian synsets were obtained automatically from a list of translational equivalents compiled form bilingual resources. Preliminary results obtained from a setof1248selectedPWNsynsetsshowthattheproducedSerbiansynsetscontain 4024 literals, out of which 2278 were offered by the system we present in this paper, whereas experts added the remaining 1746. Approximately one half of ...... EWN. Bentivogli and Pianta (2003) proposed a method for extending MultiWordNet1 with phrases, by extracting them from bilingual dictionaries and corpora with techniques similar to those used for collocation extraction. In (Bhingardive et al., 2014) a method for Sanskrit WordNet extension using a Sanskrit ...
... one of the common approaches to wordnet enhancement is the use of a developed wordnet (most commonly PWN) as the basic source for enrichment, and a method for aligning the synsets of the two wordnets, such as the ILI. Automatic alignment of synsets belonging to different languages is closely related ...
... resulting in poor recall. In methods used for automatically enriching wordnets using other available lexical resources, the successfulness of the method is strongly correlated with the comprehensiveness of the resource used in the alignment process (Hristea, 2007). Different methods and resources can ...Ranka Stanković, Miljana Mladenović, Ivan Obradović, Marko Vitas, Cvetana Krstev. "Resource-based WordNet Augmentation and Enrichment" in Proceedings of the Third International Conference Computational Linguistics in Bulgaria (CLIB 2018), May 27-29, 2018, Sofia, Bulgaria, Sofia : The Institute for Bulgarian Language Prof. Lyubomir Andreychin, Bulgarian Academy of Sciences (2018)
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Application of machine learning for diagnosing the operation of a deep well pump in oil production
Maja Trikić (2024)This paper will thoroughly examine how machine learning can improve the diagnosis of deep well pumps by analyzing the role and function of the pumps, dynamograms, sensor technologies, and diagnostic methods.Our analysis will provide insights into modern techniques and approaches for enhancing the performance and reliability of oil production systems, targeting cost reduction and increased operational efficiency.deep well pump, dynamograms, machine learning, diagnostics of operating coditions,Random Forest, XGBoost... complex number: s(k) = x(k) + jy(k) O) where k=0,1,2,...,N-1, and N represents the number of points on the contour. In this approach, the x-axis is treated as the real axis, while the y-axis is used as the imaginary axis for the sequence of complex numbers. This method has the advantage of simplifying ...
... calculating the centroid using the following equations: x= X; (8) 52 A () _1%N-1 c=yŽi=1 Ji After calculating the centroid, it is possible to use x,and y-to create a new representation of the contour, according to equation (10). z(k) — (Xx — X-) + j(yk — y-) (10) A common boundary-based shape ...
... – These use sound waves to measure flow. There are two main methods: a.Doppler method - Measures changes in the frequency of the sound wave caused by the movement of particles in the fluid. b.Transit-time method - Measures the time it takes for the sound wave to travel between two sensors, which ...Maja Trikić. Application of machine learning for diagnosing the operation of a deep well pump in oil production, 2024
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Primena AHP и WoEmetode u proceni podložnosti terena na kliženje za područje opštine Krupanj
Biljana Abolmasov, Jelka Krušić, Katarina Andrejev, Miloš Marjanović, Ranka Stanković, Uroš Đurić (2017)... municipality scale, and can be successfully used for further landsli- de risk assessment or large scale planning. Key words: landslides, AHP method, WoE method, landslide susceptibility map Adresa autora: 1,2,3,4 i 5) Univerzitet u Beogradu, Rudarsko-geološki fakultet, Đušina 7, 11000 Beograd 6) ...
... watershed, west Nepal. Computers&Geosciences 52, pp.398-408, 2013. [15] Komac M. A landslide susceptibility model using the Analytical Hierarchy Process method and mul- tivariate statistics in perialpine Slovenia. Geomorp- hology 74, pp.17-28, 2006. [16] Kubat I, Mojsilović S, Veljković D, Reljić D, Strajin ...
... Sarajevo 1968. [17] Marjanović M, Abolmasov B, Đurić U, Zečević S. Impact of geoenvironmental factors on landslide susceptibility using an AHP method: A case study of 246 IZGRADNJA 71 (2017) 7–10, 239–246 Fruška Gora Mt., Serbia. Annales Geologiques de la Peninsule Balkanique74, pp. 91-100 ...Biljana Abolmasov, Jelka Krušić, Katarina Andrejev, Miloš Marjanović, Ranka Stanković, Uroš Đurić . "Primena AHP и WoEmetode u proceni podložnosti terena na kliženje za područje opštine Krupanj" in Izgradnja, Beograd : Udruženje inženjera građevinarstva, geotehnike, arhitekture i urbanista Izgradnja (2017): 239-246
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Application of the Fuzzy theory in the evaluation of operating parameters of auxiliary mechanization on open-cast coal mine, case study: pipelayers
Achieved operating parameters are the main indicator of the work quality and selection of mining machines. The effectiveness of a coal mine is correlated with the availability of basic and auxiliary machines. The main task of auxiliary machines in lignite mines is to achieve optimal working conditions. From an economic point of view, auxiliary machines generate up to 20% of the lignite mines' total costs. These are the primary reasons for analyzing their current work and making decisions in ...Stevan Djenadić, Miloš Tanasijević, Filip Miletić, Predrag Jovančić. "Application of the Fuzzy theory in the evaluation of operating parameters of auxiliary mechanization on open-cast coal mine, case study: pipelayers" in 8th Balkan Mining Congress, Belgrade, September 28-30, Rudarski instutut (2022)
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Parameter determination of soil oscillation law using quotient of the relative growth increments of oscillation velocity and reduced distances at “Nepričava“ open pit mine
... characteristics of the soil, being determined on the basis of test blasting for the specific work environment. In this paper, an analysis of the method for the determination of soil oscillation law parameters has been conducted, suggested by Profesor M. A. Sadovski. The applicability of this law ...
... Open Pit Mine being carried out in order to exploit the deposit. To determine parameters in the equation of Sadovski, in addition to the common method of least squares, another model was applied. Thereby, it has been stated that both models can be used to calculate the oscillation velocity of the ...
... number of ways, i.e. models, thereby using values obtained by experimental measurements. Determination of parameters by model 1 The smallest square method is mainly used to obtain the parameters K and n which represents a common model (Simeunović, 1985). Determination of parameters by model 2 Proceeding ...Suzana Lutovac, Sanja Bajić, Marina Ravilić, Radmila Gaćina. "Parameter determination of soil oscillation law using quotient of the relative growth increments of oscillation velocity and reduced distances at “Nepričava“ open pit mine" in Underground Mining Engineering, Belgrade : University of Belgrade, Faculty of Mining and Geology (2015). https://doi.org/10.5937/podrad1526009L
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Numerical modelling of a single intra-oceanic subduction for the origin of the Balkan ophiolites
Nikola Stanković, Vesna Cvetkov, Vladica Cvetković. "Numerical modelling of a single intra-oceanic subduction for the origin of the Balkan ophiolites" in 5th Congress Geologists of the Republic of North Macedonia, Ohrid, 28-29. 10. 2024, Македонско геолошко друштво (2024)
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Differently shaped nanocrystalline (Fe, Y)3O4 and its adsorption efficiency toward inorganic arsenic species
Biljana P Dojčinović, Boštjan Jančar, Lotfi Bessais, Aleksandar Kremenović, Nataša P Jović-Jovičić, Predrag T Banković, Dalibor M Stanković, Miloš Ognjanović, Bratislav V Antić (2019)Herein we report effects of partial substitution of Fe3+ by Y3+ in magnetite (Fe3O4) on morphology and inorganic arsenic species adsorption efficiency of the Fe3−xYxO4 nanoparticles formed. The series of Fe3−xYxO4 (x=0.00, 0.042 and 0.084, labeled as Y00, Y05 and Y10, respectively) was synthesized using co-precipitation followed by microwave-hydrothermal treatment (MW) at 200°C. With increase of yttrium content(xvalue), both the morphological inhomogeneity of the samples and the fraction of spinel nanorods as compared to spinel pseudospherical particles increased. By ...Biljana P Dojčinović, Boštjan Jančar, Lotfi Bessais, Aleksandar Kremenović, Nataša P Jović-Jovičić, Predrag T Banković, Dalibor M Stanković, Miloš Ognjanović, Bratislav V Antić. "Differently shaped nanocrystalline (Fe, Y)3O4 and its adsorption efficiency toward inorganic arsenic species" in Nanotechnology, IOP Publishing (2019). https://doi.org/10.1088/1361-6528/ab3ca2
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Numerical Modeling and Simulation of the Effectiveness of Groundwater Source Protection Management Plans: Riverbank Filtration Case Study in Serbia
The paper describes the establishment and testing of an algorithm for developing sustainable management plans associated with groundwater source protection against potential pollutants and discusses the effectiveness of individual systems. The applied methodology pertains to groundwater resource management, particularly those cases that involve riverbank filtration. Namely, groundwater (numerical) modeling is employed to examine the groundwater regime and balance, as well as to create protection systems and illustrate their effectiveness. Particle tracking analysis is used to study pollutants’ travel and ...Dušan Polomčić, Dragoljub Bajić, Bojan Hajdin, Dragan Pamučar. "Numerical Modeling and Simulation of the Effectiveness of Groundwater Source Protection Management Plans: Riverbank Filtration Case Study in Serbia" in Water, MDPI AG (2022). https://doi.org/10.3390/w14131993
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Contents of potentially toxic elements in residual soils of a long-term mining region: a key study from Central and Western Serbia
Milun Jovanović, Dejan Prelević, Vidojko Jović, Danica Srećković-Batoćanin, Snežana Branković (2022)Regional geochemical research of residual soil was conducted in an area of about 20,000 km2 in the region of Central and Western Serbia, where six metallogenetic zones and mining since ancient times have been documented. The geochemical background variation in the residual soil was established upon the contents, spatial pattern and natural background of potentially toxic elements (PTEs). The limits of natural background values (mg·kg-1) were determined by the integral method. Our data show that anomalous concentrations of As, ...Milun Jovanović, Dejan Prelević, Vidojko Jović, Danica Srećković-Batoćanin, Snežana Branković. "Contents of potentially toxic elements in residual soils of a long-term mining region: a key study from Central and Western Serbia" in Periodico di Mineralogia (2022). https://doi.org/10.13133/2239-1002/17042
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Applicability of the risk ranking methodology designed for water reservoirs to tailings storage facilities
The risks associated with operating water reservoirs and tailings storage facilities (TSFs) are different because of their different purposes, methods of construction and operation, and characteristics of the materials impounded and their flow behaviour. Regardless of the differences, these two types of structures are often put in the same category when it comes to risk assessment and the application of relevant methodologies, which may result in unrealistic outcomes. In this paper we investigate whether it is possible to apply ...Dragana Nišić, Dinko Knežević, Aleksandar Cvjetić, Neda Nišić, Vladimir Jovanović. "Applicability of the risk ranking methodology designed for water reservoirs to tailings storage facilities" in Journal of the Southern African Institute of Mining and Metallurgy (2022). https://doi.org/10.17159/2411-9717/1492/2022
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Probabilistic analysis of anisotropic rock slope with reinforcement measures
During the construction of E75 highway through Grdelica gorge in Serbia, a major failure occurred in the zone of reinforced rock slope. Excavation was performed in highly anisotropic Paleozoic schist rock formation. The reinforcement consisted of the two rows of micropile wall with pre-stressed anchors. Forces in anchors were monitored with load cells while benchmarks were installed for superficial displacement measurements. The aim of the study is to investigate possible causes of instability considering different probability distributions of the ...Zoran Berisavljević, Dušan Berisavljević, Miloš Marjanović, Svetlana Melentijević. "Probabilistic analysis of anisotropic rock slope with reinforcement measures" in Geomechanics and Engineering (2023). https://doi.org/10.12989/gae.2023.34.3.285