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10 items
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In-vitro ispitivanje interakcija dva strukturno slična Rh(III) kompleksa Šifovih baza sa HSA/DNK i molekulski doking
Aleksandar Mijatović, Ljubica Bacetić, Nikola Pavlović, Dušan Ćoćić, Milan Nikolić, Aleksandar Lolić, Rada Baošić (2021)Kompleksi metala sa tetradentatnim Šifovim bazama ispoljavaju različitu biološku aktivnost, što omogućava ciljne sinteze novih biološki aktivnih jedinjenja. Proučavane su interakcije H[Rh(acac2en)Cl2] (1) i H[Rh(phacac2en)Cl2] (2) sa humanim serum albuminom (HSA) i sa DNK, primenom fluorescentne i UV-Vis spektroskopije (298 K, pH 7,4). Dobijene su relativno visoke vrednost dinamičke konstante vezivanja (Ksv) i to 3,88·104 M-1 za (1), 7,02·104 M-1 za (2), što ukazuje na značajno vezivanje za HSA. Izračunate konstante unutrašnjeg vezivanja (Kb) su: 2,87·105 M-1 ...Aleksandar Mijatović, Ljubica Bacetić, Nikola Pavlović, Dušan Ćoćić, Milan Nikolić, Aleksandar Lolić, Rada Baošić. "In-vitro ispitivanje interakcija dva strukturno slična Rh(III) kompleksa Šifovih baza sa HSA/DNK i molekulski doking" in 57. savetovanje Srpskog hemijskog društva , Dušan Sladić (2021)
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Cytotoxic activity of tetradentate Schiff Base Copper(II) complexes
Istraživanje kompleksa bakra kao potencijalnih antikancerogenih agenasa nudi ohrabrujuće perspektive u odnosu na komplekse platine (II) računajući na smanjenu toksičnost, novi mehanizam delovanja, različit spektar aktivnosti i perspektivu neunakrsne rezistencije. Kompleksi Šifovih baza bakra(II) koji sadrže tetradentatne ligande acac2en tipa (acac2en (1); tfacac2en (3), acactfacacen (4), acacphacacen (6)) pokazali su važnu antioksidativnu aktivnost, visok potencijal za interakciju sa HSA i DNK, u prethodnim studijama. Zbog toga je bilo interesantno ispitati i uporediti potencijal antikancerogene aktivnosti in vitro, u odnosu ...Nevenka Gligorijević, Aleksandar Mijatović, Sandra Aranđelović, Rada Baošić . "Cytotoxic activity of tetradentate Schiff Base Copper(II) complexes" in The European Association for Cancer Research 2021 , eacr2021.org/sponsorship (2021)
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Interactions of Copper(II) Complexes of some Schiff base ligands with calf thymus DNA and bovine serum albumin
Joni prelaznih metala u kombinaciji sa različitim ligandima nude veliki broj mogućnosti za ispitivanje potencijalnih bioaktivnosti. Među jonima prelaznih metala, bakar je poznat kao endogeni metal za ljude, sa karakterističnim biološkim redoks aktivnostima i relativno jakim afinitetom za nukleobaze. Kompleksi bakra ispoljavaju svoju antitumornu aktivnost na nekoliko različitih načina, generišu veliku količinu ROS, što uzrokuje oksidativno oštećenje mitohondrija i biomakromolekula. Nađeno je da kompleksi bakra(II) imaju umeren do dobar afinitet vezivanja sa DNK, uglavnom putem interkalacije.Angelina Petrović, Aleksandar Mijatović, Rada Baošić, Jovana Bogojeski. "Interactions of Copper(II) Complexes of some Schiff base ligands with calf thymus DNA and bovine serum albumin" in 6. Konferencija mladih hemičara Srbije, Srpsko hemijsko društvo (2018)
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Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases
Ispitivani su uticaji primene mono- i dvokomponentnih organskih modifikatora na određivanje lipofilnosti 12 tetradentatnih Šifovih baza metodom reverzno-fazne tankoslojne hromatografije. Osnovni cilj je da se proceni tip interakcije između posmatranih jedinjenja i komponenti primenjenih hromatografskih sistema i uspostavi neki obrazac ponašanja kako bi se lakše izabrala kombinacija organskih modifikatora koji će simulirati interakciju u biološkim sistemima na osnovu činjenica da iste osnovne intermolekularne interakcije su odgovorne za ponašanje supstanci i u biološkom i u hromatografskom sistemu. Primenjeni organski modifikator ...Nikola Stevanović, Aleksandar Mijatović, Aleksandar Lolić, Mario Zlatović, Rada Baošić. "Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases" in Chemical Papers, Springer Science and Business Media LLC (2021). https://doi.org/10.1007/s11696-021-01884-5
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Antioxidant and antimicrobial activity of some tetradentate Schiff bases and their Cu (II) complexes
Aleksandar Mijatović, Milan Nikolić, Snežana Spasić, Aleksandra N. Žerađanin, Kristina Joksimović, Aleksandar Lolić, Rada Baošić (2020)Šifove baze i njihovi Cu(II) kompleksi su poznati po svojoj biološkoj aktivnosti. U ovom radu proučavana je antibakterijska aktivnost protiv gram-negativnih sojeva Escherichia coli, Pseudomonas aeruginosa i Staphilococcus piogenes, kao i Gram-pozitivnih Staphilococcus piogenes i Pseudomonas aeruginosa, zajedno sa antifungalnim dejstvom protiv Musperg strainilusa, A. Takođe, tehnički jednostavni i brzi testovi kao što su ABTS, HORAC i ORAC korišćeni su za ispitivanje antioksidativne aktivnosti kako bi se uporedili dobijeni rezultati sa različitim tipovima testova. Uprkos tome što je princip ...Aleksandar Mijatović, Milan Nikolić, Snežana Spasić, Aleksandra N. Žerađanin, Kristina Joksimović, Aleksandar Lolić, Rada Baošić. "Antioxidant and antimicrobial activity of some tetradentate Schiff bases and their Cu (II) complexes" in XIII Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, University in Banjaluka, Faculty of Technology (2020)
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Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes
Milica Međedović, Aleksandar Mijatović, Rada Baošić, Dejan Lazić, Žiko Milanović, Zoran Marković, Jelena Milovanović, Dragana Arsenijević, Bojana Stojanović, Miloš Arsenijević, Marija Milovanović, Biljana Petrović, Ana Rilak Simović (2023)In order to discover new anticancer drugs, novel ruthenium(III) complexes [Ru(L)Cl(H2O)], where L is tetradentate Schiff base bis(acetylacetone)ethylendiimine (acacen, 1), bis(benzoylacetone)ethylendiimine (bzacen, 2), (acetylacetone)(benzoylaceton)ethylendiimine (acacbzacen, 3), bis(acetylacetone)propylendiimine (acacpn, 4), bis(benzoylacetone)propylendiimine (bzacpn, 5) or (acetylacetone)(benzoylaceton)propylendiimine (acacbzacpn, 6), were synthesized. The complexes 1 – 6 were characterized by elemental analysis, molar conductometry, and by various spectroscopic techniques, such as UV–Vis, IR, EPR, and ESI-MS. Based on in vitro DNA/BSA experiments, complexes 2 (bzacen) and 5 (bzacpn) with two aromatic rings showed ...Milica Međedović, Aleksandar Mijatović, Rada Baošić, Dejan Lazić, Žiko Milanović, Zoran Marković, Jelena Milovanović, Dragana Arsenijević, Bojana Stojanović, Miloš Arsenijević, Marija Milovanović, Biljana Petrović, Ana Rilak Simović. "Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes" in Journal of Inorganic Biochemistry, Elsevier BV (2023). https://doi.org/10.1016/j.jinorgbio.2023.112363
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Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases
The infuences of the application of mono- and two-component organic modifers on lipophilicity determination of 12 tetradentate Schif bases by reversed-phase thin layer chromatography were investigated. The main goal is to estimate types of interaction between observed compounds and components of the applied chromatographic systems and establish some behaviour pattern in order to easier choose a combination of organic modifers which will simulate interaction in biological systems based on the facts that the same basic intermolecular interactions are responsible ...Materials Chemistry, Industrial and Manufacturing Engineering, General Chemical Engineering, Biochemistry,General ChemistryNikola Stevanović, Aleksandar Mijatović, Aleksandar Lolić, Mario Zlatović, Rada Baošić. "Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases" in Chemical Papers, Springer Science and Business Media LLC (2021). https://doi.org/10.1007/s11696-021-01884-5
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In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge
Aleksandar Mijatović, Nevenka Gligorijević, Dušan Ćoćić, Snežana Spasić, Aleksandar Lolić, Sandra Aranđelović, Milan Nikolić, Rada Baošić (2023)The biological activity of six structurally similar tetradentate Schiff base copper(II) complexes, namely [Cu (ethylenediamine-bis-acetylacetonate)] (CuAA) and five derivatives where two methyl groups are replaced by phenyl, (CuPP), CF3 (CuTT) or by mixed groups CH3/CF3 (CuAT), Ph/CF3 (CuPT), and Ph/CH3 (CuAP) has been investigated. The set of antioxidant assays was performed, and the results were expressed as IC50 and EC50 values. The series of complexes showed interesting bioactivity and were investigated for the determination of antioxidant, antifungal, antimicrobial, and ...Aleksandar Mijatović, Nevenka Gligorijević, Dušan Ćoćić, Snežana Spasić, Aleksandar Lolić, Sandra Aranđelović, Milan Nikolić, Rada Baošić. "In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge" in Journal of Inorganic Biochemistry, Elsevier BV (2023). https://doi.org/10.1016/j.jinorgbio.2023.112224
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Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases
The infuences of the application of mono- and two-component organic modifers on lipophilicity determination of 12 tet radentate Schif bases by reversed-phase thin layer chromatography were investigated. The main goal is to estimate types of interaction between observed compounds and components of the applied chromatographic systems and establish some behaviour pattern in order to easier choose a combination of organic modifers which will simulate interaction in biological systems based on the facts that the same basic intermolecular interactions are ...Materials Chemistry, Industrial and Manufacturing Engineering, General Chemical Engineering, Biochemistry, General ChemistryNikola Stevanović, Aleksandar Mijatović, Aleksandar Lolić, Mario Zlatović, Rada Baošić. "Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases" in Chemical Papers, Springer Science and Business Media LLC (2021). https://doi.org/10.1007/s11696-021-01884-5
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In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge
Aleksandar Mijatović, Nevenka Gligorijević, Dušan Ćoćić, Snežana Spasić, Aleksandar Lolić, Sandra Aranđelović, Milan Nikolić, Rada Baošić (2023)The biological activity of six structurally similar tetradentate Schiff base copper(II) complexes, namely [Cu(ethylenediamine-bis-acetylacetonate)] (CuAA) and five derivatives where two methyl groups are replaced by phenyl, (CuPP), CF3 (CuTT) or by mixed groups CH3/CF3 (CuAT), Ph/CF3 (CuPT), and Ph/CH3 (CuAP) has been investigated. The set of antioxidant assays was performed, and the results were expressed as IC50 and EC50 values. The series of complexes showed interesting bioactivity and were investigated for the determination of antioxidant, antifungal, antimicrobial, and cytotoxic ...Aleksandar Mijatović, Nevenka Gligorijević, Dušan Ćoćić, Snežana Spasić, Aleksandar Lolić, Sandra Aranđelović, Milan Nikolić, Rada Baošić. "In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge" in Journal of Inorganic Biochemistry, Elsevier BV (2023). https://doi.org/10.1016/j.jinorgbio.2023.112224